The use of a medical therapeutic ozone agent in vivo to treat a variety of disorders including, but not limited to hypoxic conditions, autoimmune disease, fibrotic disease, inflammatory disease, neurodegenerative disease, infectious disease, lung disease, heart and vascular disease, metabolic disease, and cancer, wherein the therapeutic ozone agent is administered in a therapeutically effective amount, which can convert carbon monoxide to carbon dioxide and significantly raise systemic oxygen partial pressure to increase the delivery of oxygen to all tissue, systemically, to enable the reversal of hypoxic conditions of the human and animal body and the consequences of those hypoxic conditions, thereby treating or preventing the disease in a patient.
