Engineered cell comprising a recombinant pro-methylation cis-element construct that resides in a regulatory region of a target gene

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专利权人:

Baylor College of Medicine

发明人:

Lanlan Shen

申请号：

US15312986

公开号：

US10470446B2

申请日:

2015.05.21

申请国别(地区):

US

年份:

2019

代理人:

摘要：

Embodiments of the disclosure concern compositions and methods for genetic engineering related to hypermethylation of sequences. In particular embodiments, there are methods and compositions to induce DNA methylation in a manner that leads to transcriptional suppression of a target gene that allows characterization of the gene and/or its expression.

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