A system and method of diagnosing tissue integrity related to a joint of a patient may include imaging a first bone of the joint of the patient, determining a bone density profile of the first bone based on results of the imaging step, comparing the bone density profile of the first bone to at least one reference bone density profile of a reference first bone, and predicting an integrity of a tissue with respect to the first bone based on the comparison. The first bone may be a tibia and the bone density profile of the tibia may include a bone density profile of a sulcus of a medial tibial condyle of the tibia. The tissue may be an anterior cruciate ligament (“ACL”) and the predicting step may include predicting the integrity of both an anteromedial bundle and a posterolateral bundle of the ACL.
