An apparatus and method for placement of a lead for cardiac resynchronization therapy in a cardiovascular system of patient. A conductive tool is advanced along at least one branch of the cardiovascular system of the patient. Electrogram data of the cardiovascular system at each location of the conductive tool along the cardiovascular system using the conductive tool is obtained while the conductive tool is advanced. The electrogram data is analyzed to determine a morphological condition of tissue of the patient surrounding the location.