Polymeric biguanide compositions containing terminal amine groups of less than 18 mol% as determined by 13C NMR. Polymeric biguanide composition is also characterized by a relative increase in the molar concentration of the terminal cyanoguanidino terminal group or guanidine group. The present invention also, I also directed to an ophthalmic composition comprising a polymeric biguanide composition. The polymeric biguanide composition, as antimicrobial components of ophthalmic lens care solution, or can be used as a preservative for health care products or other pharmaceutical composition.13C NMRによる測定で18モル%未満の末端アミン基を含む高分子ビグアニド組成物。該高分子ビグアニド組成物は、末端グアニジン基又は末端シアノグアニジノ基のモル濃度の相対的増加によっても特徴付けられる。本発明はまた、該高分子ビグアニド組成物を含む眼科用組成物にも向けられる。該高分子ビグアニド組成物は、眼科用レンズケア溶液中の抗菌成分として、又は医薬組成物もしくはその他のヘルスケア製品中の保存剤として使用できる。
