Zhu, Guidong,Gong, Jianchun,Gandhi, Virajkumar B.,Giranda, Vincent,Penning, Thomas D.
申请号：
AU2012200398
公开号：
AU2012200398A1
申请日:
2012.01.23
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2012200398A120120216.pdf#####1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH A QUATERNARY CARBON AT THE 2-POSITION ARE POTENT PARP INHIBITORS Abstract 5 Compounds of Formula (I) 0 NH2 R1 N A N R2 H R3 (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated 1o with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
