Kevin P. Brower,Chris Hwang,Rao Koduri,Konstantin B. Konstantinov,Veena Warikoo,Marcella Yu,Jin Yin
申请号：
US14668820
公开号：
US10647777B2
申请日:
2015.03.25
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Disclosed herein are methods that have been developed to control the formation of disulfide bonds between polypeptides of a multimeric protein produced by a bioprocess. Also disclosed are protein solution parameters that allow for controlling the formation of disulfide bonds. In one example, the methods disclosed herein can be used to control the proportion of half antibody molecules in an antibody solution.
