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Protein Polymer microparticles
专利权人:
ИНК. (US);РИДЖЕНЕРОН ФАРМАСЬЮТИКАЛЗ
发明人:
ЧЕН Хантер (US),УОЛШ Скотт (US)
申请号:
RU2014124682/15
公开号:
RU2014124682A
申请日:
2012.11.18
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A composition comprising a protein, polymer coated, wherein the composition is a particle diameter from about 5 microns to about 40 mkm.2. Composition according to Claim. 1, wherein the protein is an antigen belok.3. The composition of claim. 2, in which the protein is antitelo.4. A composition according to claim. 2, wherein the protein is a fusion protein-Fc-retseptor.5. A composition according to claim. 2, wherein the protein is a fragment antitela.6. A composition according to claim. 4, wherein the protein is a trap-VEGF.7. A composition according to claim. 3, wherein the antibody is a human monoclonal antitelo.8. Composition according to Claim. 1, wherein the polymer is a biodegradable polimer.9. Composition according to claim. 8, wherein the polymer is selected from the group consisting of polylactic acid (PLA), polyanhydride, poly [1,6-bis (p-carboxyphenoxy) hexane] (pCPH), a copolymer of hydroxybutyric acid with hydroxyvaleric acid (PHB-PVA ) copolymer, polyethyleneglycol-polylactic acid (PEG-PLA), poly-D, L-lactide-co-glycolide (PLGA), polyorthoester (POE), ethylcellulose (EC), and poly-ε-caprolactone (PCL) .10. A composition according to claim. 8, in which the protein is either trapped, or antibody, and the polymer is a POE.11. Composition according to claim. 10 wherein the average particle diameter is approximately 15 mkm.12. A composition according to claim. 8, in which the protein is either trapped or antibody, and the polymer is a PLGA.13. A microparticle having a diameter of from about 2 microns to 70 microns, including the core protein particles with a diameter from 2 microns to 12 microns and a top layer of a biodegradable polimera.14. The microparticle of claim. 13 wherein the biologically destroyed1. Композиция, содержащая белок, покрытый полимером, где композиция представляет собой частицу с диаметром от приблизительно 5 мкм до приблизительно 40 мкм.2. Композиция по п. 1, в которой белок представляет собой антигенсвязывающий белок.3. Композиция
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