ポリマー複合体を調製する方法

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专利权人:

ネクター セラピューティクス

发明人:

チャン, ウェン

申请号：

JP2009539338

公开号：

JP5277417B2

申请日:

2007.11.30

申请国别(地区):

JP

年份:

2013

代理人:

摘要：

Provided herein is a straightforward and efficient method for covalently attaching a polyethylene glycol polymer to docetaxel. The method involves, among other things, a step of reacting docetaxel with a polyethylene glycol polymer comprising a functional group reactive with a hydroxyl group within docetaxel in the presence of a coupling reagent and DPTS. The result of the reacting step is the formation of a polyethylene glycol-docetaxel conjugate having a single polyethylene glycol covalently attached, via an ester linkage, to the hydroxyl group within docetaxel.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/