PROBLEM TO BE SOLVED: To provide compositions and methods for protection in a patient suffering from an eye disease such as age-related macular degeneration, and to provide a method for administering the same.SOLUTION: A solution containing a compound selected from tetramethylpyrazine, hydralazine, and guanabenz is topically administered to an eye.COPYRIGHT: (C)2013,JPO&INPIT【課題】加齢性黄斑変性などの眼疾患を患っている患者における保護を目的とした組成物およびその投与方法の提供。【解決手段】テトラメチルピラジン、ヒドララジン、グアナベンズから選ばれる化合物を含む溶液を眼に局所投与する。【選択図】なし