Therapy system for treatment of an animate body including core body cooling. The system includes a therapy wrap and a first therapy device for exchanging heat with the body. The system may include a second therapy device for delivering another therapy. The first therapy device may include a heat transfer device, a cooling or heating source, and a control unit. The heat transfer device may include a fluid bladder and a compressive bladder. The second therapy device may be an electric stimulation device. The therapy wrap is adapted to coordinate delivery of the thermal therapy and another therapy to the animate body. The therapy wrap may also be a sleeve for mounting components of the first and second therapy devices. Also disclosed are a method of administering a temperature-controlled treatment to an anatomical body part and method of making the therapy system.
