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Benzothienyl-substituted pyrrolotriazines and their uses in cancer treatment
专利权人:
Bayer Intellectual Property GmbH;Bayer Pharma Aktiengesellschaft
发明人:
COLLIN, Marie-Pierre,BROHM, Dirk,HEROULT, Mélanie,LOBELL, Mario,HÜBSCH, Walter,LUSTIG, Klemens,GRÜNEWALD, Sylvia,BÖMER, Ulf,VÖHRINGER, Verena,LINDNER, Niels
申请号:
ES12809680
公开号:
ES2570862T3
申请日:
2012.12.11
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
A compound of formula (I) ** Formula ** in which R1 is hydrogen, chlorine, methyl or methoxy, R2 is hydrogen or methoxy, with the proviso that at least one of R1 and R2 is other than hydrogen, and G represents the group -CH2-OR3, -C (>; = O) -OR3, -CH2-NR4R5 or -C (>; = O) -NR4R6, in which R3 is hydrogen or (C1-C4) alkyl optionally substituted with cyano , hydroxy, (C1-C4) alkoxy, hydroxycarbonyl, (C1-C4) alkoxycarbonyl, amino, monoalkylamino (C1-C4), dialkylamino (C1-C4), pyrrolidino, piperidino, morpholino, aminocarbonyl, monoalkylaminocarbonyl (C1-C4), dialkylaminocarbonyl (C1-C4) or up to three fluorine atoms, R4 is hydrogen or (C1-C4) alkyl, R5 is hydrogen, (C1-C4) alkyl, alkyl (C1-C4) alkyl, cycloalkyl (C3-C6) or heterocycloalkyl 4 to 6 members, wherein (i) said (C1-C4) alkyl is optionally substituted with cyano, hydroxy, (C1-C4) alkoxy, (C1-C4) alkoxycarbonyl, aminocarbonyl, mono-alkylaminocarbonyl (C1-C4), dialkylaminocarbonyl (C1-C4), alkyl arbonylamino (C1-C4) or up to three fluorine atoms, and (ii) said cycloalkyl (C3-C6) is optionally substituted with one or two substituents independently selected from the group consisting of (C1-C4) alkyl, hydroxy, amino and (C1-C4) alkylcarbonylamino, and (iii) said 4- to 6-membered heterocycloalkyl is optionally substituted with one or two substituents independently selected from the group consisting of (C1-C4) alkyl, hydroxy, oxo, amino and alkylcarbonylamino ( C1-C4), R6 is hydrogen, (C1-C4) alkyl, (C3-C6) cycloalkyl or 4-6 membered heterocycloalkyl, in which (i) said (C1-C4) alkyl is optionally substituted with hydroxy, alkoxy (C1-C4), alkoxycarbonyl (C1-C4), amino, aminocarbonyl, monoalkylaminocarbonyl (C1-C4), dialkylaminocarbonyl (C1-C4) or alkylcarbonylamino (C1-C4), and (ii) said cycloalkyl (C3-C6) is optionally substituted with one or two substituents independently selected from the group consisting iste in (C1-C4) alkyl, hydroxy, amino and (C1-C4) alkylcarbonylamino, and (iii) said 4- to 6-membered heter
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