Provided is a method for enhancing yield-related traits in plants by increasing expression in plants of a nucleic acid encoding a Low Sulfur Upregulated polypeptide (LSU). Also provided are plants having increased expressing of a nucleic encoding an LSU polypeptide, which have enhanced yield-related traits compared with control plants. Also provided are LSU-encoding nucleic acids, and constructs comprising the same, useful in enhancing yield-related traits in plants.