The present invention relates to combination methods for treating diseases or conditions in which proprotein convertase subtilisin/kexin type 9 (PCSK9) expression or activity causes an impact by administration of PCSK9-specific antibodies or antigen-binding fragments thereof. The present invention further relates to PCSK9-specific antibodies or antigen-binding fragments thereof for use in the combination treatment of diseases or conditions in which PCSK9 expression or activity causes an impact.The present invention also relates to articles of manufacture comprising packaging material, PCSK9-specific antibodies or antigen-binding fragments thereof, a fibrate and/or a lipid lowering drug acting by inhibiting cholesterol uptake, together with a label or packaging.insert.
