BROOKS, PETER,CHERESH, DAVID A.,FRIEDLANDER, MARTIN
申请号：
CA2754102
公开号：
CA2754102C
申请日:
1996.08.13
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention describes methods for inhibiting angiogenesis in tissues using vitronectin .alpha.v.beta.5 antagonists. The present invention provides monoclonal antibodies, and compositions comprising such, which are useful in the inhibition of .alpha.v.beta.5 mediated angiogenesis. The .alpha.v.beta.5- mediated angiogenesis is correlated with exposure to cytokines including vascular endothelial growth factor, transforming growth factor-.alpha. and epidermal growth factor. Inhibition of .alpha.v.beta.5-mediated angiogenesis is particularly preferred in vascular endothelial ocular neovascular diseases, in tumor growth and in inflammatory conditions, using therapeutic compositions containing .alpha.v.beta.5 antagonists.
