There is disclosed compositions and methods relating to or derived from anti-TIM3 antibodies. More specifically, there is disclosed fully human antibodies that bind TIM3, TIM3-antibody binding fragments and derivatives of such antibodies, and TIM3-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating a disease.本發明揭示與抗TIM3抗體有關或來源於抗TIM3抗體之組合物及方法。更特定言之,揭示結合TIM3之完全人類抗體、TIM3抗體結合片段及此類抗體之衍生物,及包含此類片段之TIM3結合多肽。另外,揭示編碼此類抗體、抗體片段以及衍生物及多肽之核酸,包含此類聚核苷酸之細胞,製備此類抗體、抗體片段以及衍生物及多肽之方法,以及使用此類抗體、抗體片段以及衍生物及多肽之方法,包括治療疾病之方法。