BINDER, JEFFREY R.,HIGGINS, JOEL C.,LEACH, MICHAEL D.,O'SHAUGHNESSEY, KRISTA,WOODELL-MAY, JENNIFER E.,OSHAUGHNESSEY, KRISTA
申请号：
CA2916081
公开号：
CA2916081A1
申请日:
2014.02.18
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Methods for making non-immunogenic anti-inflammatory cytokine compositions, comprising (a) obtaining a liquid comprising cytokine producing cells from a mammalian donor； (b) contacting the liquid with a solid extraction material to generate a composition rich in interleukin-1 receptor antagonist； and performing one or both of (i) removing cells from the composition and (ii) freezing the composition. The compositions comprise two or more of IL1-ra, sTNF-R1, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-ß1, and sIL-1RII, Compositions may also contain white blood cells and platelets.
