Carlos Enrique Lenhard,Harold Monro Moody,Theodorus Johannes Godfried Maria Van Dooren
申请号：
US12300046
公开号：
US08420806B2
申请日:
2007.05.11
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to a process for the preparation of cefadroxil in crystal form, comprising a) adding an aqueous solution of cefadroxil to a crystallization vessel and a titrant to keep a pH in the crystallization vessel of between 7 to 9 and b) lowering the pH in the crystallization vessel to a value of between 5 and 6.5 to obtain a suspension of the β-lactam compound in crystal form. The invention further relates to cefadroxil in crystal form obtainable by the process according to the present invention. The invention also relates to cefadroxil in crystal form with a CIE b value of below 12 when stored at a temperature of 25° C. for at least 1 month.
