HUMPHREYS, DAVID PAUL,ADAMS, RALPH,HEADS, JAMES,PETERS, SHIRLEY JANE
申请号：
CA2807227
公开号：
CA2807227A1
申请日:
2011.08.19
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention provides an antibody of the class IgG4 comprising at least one heavy chain which comprises a CH1 domain and a hinge region, wherein in each heavy chain: a. the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid； and b. one or more of the amino acids positioned in the upper hinge region is substituted with cysteine.
