Eszter Nagy,Adriana Badarau,Harald Rouha,Lukas Stulik,Gábor Nagy,Irina Mirkina,Zoltán Magyarics,Zehra Visram,Michaela Jaegerhofer,Manuel Zerbs,Ivana Dolezilkova,Astrid Teubenbacher,Michael Benjamin Ba
申请号:
US14395259
公开号:
US09914767B2
申请日:
2013.04.17
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The subject relates to a cross-neutralizing antibody comprising at least one polyspecific binding site that binds to alpha-toxin (Hla) and at least one of the bi-component toxins of Staphylococcus aureus, its medical and diagnostic use, method of producing the antibody, including an isolated nucleotide sequence, plasmids and host cells as used in the production of the antibody; and further an isolated conformational epitope recognized by a specific cross-neutralizing antibody.