VENKATESH, GOPI,BOLTRI, LUIGI,COLOMBO, ITALO,LAI, JIN-WANG,FLABIANI, FLAVIO,MAPELLI, LUIGI
申请号：
NZ57517107
公开号：
NZ575171A
申请日:
2007.08.29
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is a pharmaceutical composition comprising timed pulsatile release (TPR) beads, wherein said TPR beads comprise: a solid dispersion of at least one active pharmaceutical ingredient in at least one solubility-enhancing polymer and a TPR coating comprising a water insoluble polymer and an enteric polymer wherein the active pharmaceutical ingredient comprises a weakly basic active pharmaceutical ingredient having a solubility of not more than 100 ìg/mL at pH 6.8 and wherein the active pharmaceutical ingredient is substantially amorphous.
