METHOD FOR PRODUCING PROTON PUMP INHIBITOR COMPOUND HAVING OPTICAL ACTIVITY
- 专利权人:
- 发明人:
- NAKAMURA EIICHI,ILIES LAUREAN,ODERAOTOSHI YOJI,IZUMI TAKUHIRO,NISHIGUCHI SHIGENOBU
- 申请号：
- IN201717021616
- 公开号：
- IN201717021616A
- 申请日:
- 2017.06.20
- 申请国别(地区):
- IN
- 年份:
- 2017
- 代理人:
- 摘要：
A highly pure optically active proton pump inhibitor compound can be produced safely and inexpensively in a high yield and enantioselectivity by a method of producing an optically active sulfoxide of Formula 2 or a salt thereof, comprising oxidizing a sulfide of Formula 1 or a salt thereof with hydrogen peroxide using an iron salt in the presence of a chiral ligand of Formula 3 wherein A is CH or N R 1 is hydrogen atom, an alkyl optionally substituted by halogen(s), or an alkoxy optionally substituted by halogen(s) one to three R 2 may exist, and each of R 2 is independently an alkyl, a dialkylamino, or an alkoxy optionally substituted by halogen(s) or alkoxy(s) each of R 3 is independently hydrogen atom, a halogen, cyano or the like R 4 is a tertiary alkyl and * and ** represent respectively R configuration or S configuration.
[EP3239146A1]
- 来源网站：
- 中国工程科技知识中心
