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IMIDAZO [1, 2-B] Pyridazine Compounds, Compositions of Such Compounds and Methods of Their Use
专利权人:
ИНК. (US);ЛЕКСИКОН ФАРМАСЬЮТИКАЛЗ
发明人:
БИ Инчжи (US),КАРСОН Кеннет Гордон (US),ЧИАНКЕТТА Джованни (US),ГРИН Майкл Алан (US),КУМИ Годвин (US),ЛЯН Чжи (US),ЛЮ Ин Джейд (US),МЭЙН Алан (US),ЧЖАН Юлянь (US),ЗИПП Гленн Грегори (US)
申请号:
RU2014140739
公开号:
RU2014140739A
申请日:
2013.03.05
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. The compound of the formula: or a pharmaceutically acceptable salt thereof, wherein: A is a cyclic C-hydrocarbyl or a 4-7 membered heterocycle; D is a 4-7 membered heterocycle; each R independently is —OR, —N (R), - C (O) R, —C (O) OR, —C (O) N (R), —N (R) C (O) OR, cyano, halogen or optionally substituted C-hydrocarbyl or 2-12 membered heterocarbyl, where optional substitution means optional substitution with one or more R substituents; each R independently represents —OR, —N (R), —C (O) R, —C (O) OR, —C (O) N (R), —N (R) C (O) OR, cyano or halogen; each R is independently is hydrogen or an optionally substituted C-hydrocarbyl or 2-12 membered heterocarbyl, where optional substitution means optional substitution with one or more substituents selected from cyano, halogen or hydroxyl; each R is independently —OR, —N (R), —C ( O) R, -C (O) OR, -C (O) N (R), -N (R) C (O) OR, cyano, halogen or optionally substituted C-hydrocarbyl or 2-12 membered heterocarbyl, where optional substitution means optional substitution with one or more substituents selected from amino, cyano, halogen, hydr xylitol or R; each independently represents hydrogen or optionally substituted Cgidrokarbil or 2-12 membered heterocarbyl, where optional substitution is optionally substituted with one or more substituents selected from amino, cyano, hydroxyl or halogen; n has a value of 1-3; and m has a value of 0-3; under conditions that: 1) R is different from hydroxyl or optionally substituted phenyl or pyridinyl; 2) when D is diazapine and A is pyridinyl, R is different from —C (O) O-tert-butyl; 3) when D is piperazine, A is phenyl and R is chlorine, R is1. Соединение формулы:или его фармацевтически приемлемая соль, где:A представляет собой циклический Cгидрокарбил или 4-7-членный гетероцикл;D представляет собой 4-7-членный гетероцикл;каждый Rнезависимо представляет собой -OR, -N(R), -C(O)R, -C(O)OR, -C(O)N(R), -N(R)C(O)OR, циано, галоген или необязательно замещенный Cгидрокарбил или 2-12-членный
来源网站:
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