Claim 1: a compound and pharmaceutically acceptable salts, solvates, or stereoisomers, isotopic variants of these N - oxides, which have a structure of formula (1),Where is r¹ h； ch₂f； or ch₃； R² is selected from the group consisting of phenyl substituted phenyl； with one, two or three members,Each independently selected from the group consisting c₁₋₆ alkyl, Halo, haloalquilo c₁₋₆, CN, or - alkyl - or c₁₋₆, haloalquilo c₁₋₆,N (ch₃) ₂ pyridinyl substituted pyridinyl and ciclopropilo；； F,C₁₋₄ haloalquilo c₁₋₄ alkyl or alkyl substituted thiazolyl；；； c₁₋₆ or haloalquilo c₁₋₆； tienilo； and tienilo replaced with one or two membersEach independently selected from the group consisting c₁₋₆ alkyl, Halo, haloalquilo c₁₋₆, ch₂oh,Ch₂och₃ and ciclopropilo； r³ is h； r⁴ is selected from the group consisting of: (a) a compound of formula (2),By donde of anillo a es un Tao 4 - October 6 Post a contiene opcionalmente un heteroátomo serves oxígeno adicional seleccionado del Grupo a consiste. Azetidinilo； azetidinilo sustituido byOne or Two Selected members regardless of the group consisting of: F, Oh, alkyl c₁₋₄, haloalquilo c₁₋₄, ch₂och₃,Cn and och₃； pirrolidinilo； pirrolidinilo replaced two members morfolinilo； F； piperidinilo； piperazinilo substituted with alkyl c₁₋₆ 2,6-diazaspiro [； and (3).3] heptan - il - 6)； (b) a compound of formula (3),Where r⁴ᵇ is selected from the group consisting of H, alkyl, cycloalkyl c₃₋₆ ch₂ch₂och₃ c₁₋₆；；； c₃₋₆ cycloalkyl substituted with two or three members selected irrespective of Group QEU is f or ch₃； oxetanilo； oxetanilo substituted pyridinyl ch₃； and； (c) a compound of formula (4),Where r⁴ᶜ is selected from the group consisting ciclopropilo； ciclopropilo replaced with one or two members F； CH (OH) ciclopropilo； azetidinilo； ch₂ - azetidinilo； ch₂ - azetidinilo replaced with uTwo Selected members whether or not: (F, ohOch₃ and cf₃； oxetanilo； oxetanilo replaced with F or ch₃； tetrahidrofuranilo； tetrahidropiranilo； ch₂ - pirrolidinilo； ch₂ - pir
