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Derivatives of rufinamide and their use in inhibtion of the activation of human voltage-gated sodium channels
专利权人:
发明人:
Frank Bosmans,Jeet Kalia
申请号:
US14814702
公开号:
US09771335B2
申请日:
2015.07.31
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The present invention provides compounds of formula I which are capable of inhibition of the activation of hNav1.1 or hNav1.6 sodium channels in neurons. Pharmaceutical compositions comprising these compounds are also provided. Methods for prevention and treatment of neurological disorders, including, for example, seizures and seizure disorders, including Lennox-Gastaut Syndrome, Dravet syndrome, epileptic encephalopathies, autism, Familial hemiplegic migraine (FHM), anxiety disorders, including Post-traumatic stress disorder (PTSD), panic disorder and obsessive-compulsive disorder, neuropathic pain, and Rett syndrome by administration of these compounds are also provided.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
相关发明人
frank bosmans
jeet kalia
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