Lysosomal targeting peptides and uses thereof

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专利权人:

发明人:

Jonathan H. LeBowitz,John Maga

申请号：

US14535505

公开号：

US09469683B2

申请日:

2014.11.07

申请国别(地区):

US

年份:

2016

代理人:

摘要：

The present invention provides further improved compositions and methods for efficient lysosomal targeting based on the GILT technology. Among other things, the present invention provides methods and compositions for targeting lysosomal enzymes to lysosomes using furin-resistant lysosomal targeting peptides. The present invention also provides methods and compositions for targeting lysosomal enzymes to lysosomes using a lysosomal targeting peptide that has reduced or diminished binding affinity for the insulin receptor.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/