SACCOMANO, Sam,CAPEHART, Stacy,EATON, Bruce,BERRY, Karin Zemski
申请号：
USUS2019/039848
公开号：
WO2020/006423A1
申请日:
2019.06.28
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Chemical syntheses of guide molecules are disclosed, along with compositions and methods relating thereto. A cost-effective and straightforward chemical synthesis of high-purity unimolecular guide molecules with minimal n-1 and/or n+1 species, truncation species, and other contaminants by providing, among other things, methods for synthesizing unimolecular guide molecules that involve cross-linking two or more pre-annealed guide fragments.L'invention concerne des synthèses chimiques de molécules de guidage, ainsi que des compositions et des procédés s'y rapportant.
