UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人:
FREEMAN, BRUCE, A.
申请号：
DK08780348
公开号：
DK2180787T3
申请日:
2008.08.01
申请国别(地区):
DK
年份:
2014
代理人:
摘要：
Nitro oleic acid and related metabolites are agonists of PPAR-³. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-³, relative to nitro linoleic acid. Thus, nitro oleic acid and its metabolites, as well as their pharmaceutically acceptable salts and prodrug forms, are candidate therapeutics for the treatment of type-2 diabetes, which results from insulin resistance accompanying the improper functioning of PPAR-³.
