Provided in some embodiments are methods for inducing an antigen-specific immune response in a subject, comprising administering a compound having a structure according to Formula A or Formula B: or a pharmaceutically acceptable salt, tautomer or hydrate thereof, where X is a bond or linker, X is -P0-, and X, R, R, R, and n are described herein. Also provided in some embodiments are methods for making and using such compounds and compositions.
