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ХИНОЛИНЫ В КАЧЕСТВЕ МОДУЛЯТОРОВ FGFR КИНАЗЫ
专利权人:
ASTEKS TERAPYUTIKS LIMITED
发明人:
BERDINI Valerio,БЕРДИНИ Валерио,ANZHIBO Patrik Rene,АНЖИБО Патрик Рене,VUDKHED Stiven Dzhon,ВУДХЭД Стивен Джон,SAKSTI Gordon,САКСТИ Гордон
申请号:
RU2014121494
公开号:
RU0002625303C2
申请日:
2012.10.26
申请国别(地区):
RU
年份:
2017
代理人:
摘要:
FIELD: pharmacology.SUBSTANCE: invention related to a new quinoline derivative of formula (I), where W us -N(R3)- or -C(R3aR3b)- each R2 is independently selected from halogen, C1-4alkoxy, Y is -E-D D is phenyl or 5-6-membered monocyclic heterocyclyl, containing one or two heteroatoms selected from N or O, wherein the mentioned heterocyclyl can be optionally substituted with one group of R1 E is a link R1 is hydrogen, C1-6alkyl, hydroxyC1-6alkyl, C1-6alkyl which is substituted with -S(=O)2-C1-6alkyl, R6 R3a is hydroxyl, hydroxyC1-6alkyl, cyanoC1-6alkyl, C1-6alkyl which is substituted with -NR10R11, C1-6alkyl which is substituted with -C(=O)-NR10R11 R3b is hydrogen or R3a and R3b are combined to obtain =O or to obtain =CH-C0-4alkyl which is substituted with R3c R3c is cyano R3 is C2-6alkynyl, hydroxyC1-6alkyl, hydroxyhaloC1-6alkyl, C1-6alkyl which is substituted with R9, C2-6alkynyl which is substituted with R9, C1-6alkyl which is substituted with -NR10R11 R6 is 6-membered monocyclic heterocyclyl, containing one O atom R9 is 5- or 6-membered monocyclic heterocyclyl, containing one or two heteroatoms, seleceted from N or O, each is optionally and each is independently substituted with substitute selected from =O, C1-4alkyl, C1-4alkoxy, S(=O)2-NR14R15, C1-4alkyl which is substituted with -NH-S(=O)2-haloC1-4alkyl, 6-membered aromatic monocyclic heterocyclyl, containing two N atoms, wherein the mentioned heterocyclyl is optionally substituted with R16 each R10 and R11 independently represent hydrogen, C1-6alkyl, haloC1-6alkyl each R14 and R15 independently represent C1-4alkyl R16 is C1-4alkoxy n independently represent a whole number equal to 2, 3 or 4 as well as to its pharmaceutically acceptable salt and to any tautomeric or stereochemically isomeric form thereof. The invention also relates to pharmaceutical compositions based on compound of formula (I), application of the compound of formula (I), method for the prevention or treatment of a disease and product based o
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