The present Invention provides an isolated Antibody that binds to the C domain of fibrin or Fibrinogen. In several respects the Antibody inhibited The Adherence to the domain of microglial YC fibrin or Fibrinogen, Inhibits the binding of mac-1 to fibrin or Fibrinogen C domain.La presente invención provee un anticuerpo aislado que se une al dominio YC de fibrina o fibrinógeno. en varios aspectos, el anticuerpo inhibe la adhesión microglial al dominio YC de fibrina o fibrinógeno, inhibe la unión del Mac-1 al dominio YC de fibrina o fibrinógeno.