Disclosed herein are solutions and kits for tumescent antibiotic delivery. Embodiments of the solution comprise an antibiotic component an anesthetic component and a vasoconstrictor component. In addition a method of use is disclosed comprising subcutaneous delivery of the solution. The disclosed solution kit and method of subcutaneous delivery can be used for a variety of surgical procedures including liposuction mastectomy and others. The tumescent antibiotic solution can be administered to a patient in situations where establishing IV access is difficult impossible or undesirable. A variety of delivery methods appropriate for surgical settings as well as for use by first responders are likewise disclosed.