THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SER;EMORY UNIVERSITY
发明人:
Marjan Huizing,William A. Gahl,Nuria Carrillo-Carrasco,Miao He,Xueli Li,Rong Jiang
申请号：
US14775507
公开号：
US20160025717A1
申请日:
2014.03.13
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Methods are disclosed for diagnosing a hyposialylation disorder. Methods are also disclosed for determining the effectiveness of a therapeutic agent for treatment of a hyposialylation disorder in a subject. These methods include measuring an amount of monosialylated Thomsen-Friedenreich (ST) antigen and measuring an amount of non-sialylated Thomsen-Friedenreich antigen (T) in a biological sample, such as a serum or plasma sample from the subject, and determining the ratio of T to ST.
