Antimicrobial compositions, especially those useful when applied topically,particularly to mucosal tissues (i.e., mucous membranes), including a cationicantiseptic such as biguanides and bisbiguanides such as chlorhexidine and itsvarious salts including but not limited to the digluconate, diacetate,dimethosulfate, and dilactate salts; polymeric quaternary ammonium compoundssuch as polyhexamethylenebiguanide; silver and various silver complexes; smallmolecule quaternary ammonium compounds such as benzalkoium chloride and alkylsubstituted derivatives; di-long chain alkyl (C8-C18) quaternary ammoniumcompounds; cetylpyridinium halides and their derivatives; benzethoniumchloride and its alkyl substituted derivatives; and octenidine. Thecompositions can also include an enhancer component, a surfactant, ahydrophobic component, and/or a hydrophilic component. Such compositionsprovide effective topical antimicrobial activity and are accordingly useful inthe treatment and/or prevention of conditions that are caused, or aggravatedby, microorganisms (including viruses).