Disclosed are 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, their stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof； compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Disclosed also are methods of using the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cellular proliferative, viral, autoimmune, cardiovascular, and central nervous system diseases.本發明揭示2－胺基－7,8－二氫－6H－吡啶并[4,3－d]嘧啶－5－酮化合物、其立體異構體、互變異構體、醫藥上可接受之鹽及其前藥；包含一醫藥上可接受之載劑及一或多種2－胺基－7,8－二氫－6H－吡啶并[4,3－d]嘧啶－5－酮化合物(單獨或與至少一種額外治療藥劑組合使用)之組合物。本發明亦揭示在預防或治療細胞增生、病毒性、自身免疫性、心血管及中樞神經系統疾病中單獨或與至少一種額外治療藥劑組合使用2－胺基－7,8－二氫－6H－吡啶并[4,3－d]嘧啶－5－酮化合物之方法。
