PROBLEM TO BE SOLVED: To provide a technique to prevent a decrease in the content of a halogenated isoquinoline derivative in an aqueous composition containing the halogenated isoquinoline derivative and timolol.SOLUTION: The present invention provides an aqueous composition for prevention or treatment of at least one disease selected from ocular hypertension and glaucoma, containing following components (A), (B) and (C): (A) a compound represented by formula (1) or a salt thereof or their solvates (B) timolol or a salt thereof or their solvates (C) at least one selected from arginine, histidine, lysine, monoethanolamine, ethylenediamine and a salt thereof and their solvates. [X is a halogen atom].SELECTED DRAWING: NoneCOPYRIGHT: (C)2018,JPO&INPIT【課題】ハロゲン化イソキノリン誘導体及びチモロールを含有する水性組成物中の、ハロゲン化イソキノリン誘導体の含量低下を抑制する技術の提供。【解決手段】次の成分(A)、(B)及び(C)を含有する、高眼圧症及び緑内障から選ばれる1種以上の疾患の予防又は治療用の水性組成物:(A)式(1)で表される化合物若しくはその塩又はそれらの溶媒和物;(B)チモロール若しくはその塩又はそれらの溶媒和物;(C)アルギニン、ヒスチジン、リシン、モノエタノールアミン、エチレンジアミン及びそれらの塩並びにそれらの溶媒和物より選ばれる1種以上。[Xはハロゲン原子]【選択図】なし
