Dérivés de 3-aminopyrrolidine en tant que modulateurs de récepteurs de chimiokine

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专利权人:

Incyte Corporation

发明人:

申请号：

EP11175373.7

公开号：

EP2431357A2

申请日:

2003.11.26

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

The present invention relates to 3-aminopyrrolidine derivatives of the formula I:(wherein R1, R2, R3, R4, R5, R6, R7, R8, X, Y and X are as defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of chemokine receptors and more specifically as a modulator of the CCR2 and/or CCR5 receptor. The compounds and compositions of the invention may bind to chemokine receptors, e.g., the CCR2 and/or CCR5 chemokine receptors, and are useful for treating diseases associated with chemokine, e.g., CCR2 and/or CCR5, activity, such as atherosclerosis, restenosis, lupus, organ transplant rejection and rheumatoid arthritis.

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