Shenzhen in Vivo Biomedicine Technology Limited Company
发明人:
Li, Peng,Lai, Yunxin,Lin, Simiao,Yao, Yao
申请号：
AU2015376656
公开号：
AU2015376656A1
申请日:
2015.08.07
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
#$%^&*AU2015376656A120170223.pdf#####ABSTRACT The present invention relates to a chimeric antigen receptor, a nucleic acid encoding the same and a cell expressing the same, and their use in manufacturing drugs for treating tumors. The chimeric antigen receptor of the present invention is characterized by its intracellular domain including at least Toll-like receptor 1 and/or Toll-like receptor 2 intracellular domain(s)； compared to the prior art, the chimeric antigen receptors of the present invention has significant advantages in T cell expansion, cytotoxicity, T cell invasion and migration, eliminating immunosuppressive effect of regulatory T cells and promoting the formation of memory T cells, etc.
