Mohammad Rashidian,Hidde L. Ploegh,Neil Vasdev,Huan Steven Liang
申请号：
US15764087
公开号：
US20180280551A1
申请日:
2016.10.01
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided herein are methods for producing site specific PEG modifications to single domain antibodies (e.g., VHHs). Methods for producing site-specific ally conjugated bivalent single domain antibodies (e.g., VHHs) are also provided. Methods for labeling (e.g., with a fluorophore or radionuclide) site-specifically PEGylated single domain antibodies and site-specifically conjugated bivalent single domain antibodies are also provided.
