A variable pressure acupressure device of the invention includes a plurality of spaced apart applicators arranged on a belt for positioning over the required sensitive areas on the body. Patient-specific configuration and size of the device may be adjusted by selecting a number of applicators as well as their locations to match the desired locations for a patient, including linear, non-linear and two-dimensional configurations. Each applicator may be activated individually from a central controller in accordance with a predetermined acupressure sequence. The degree of skin compression may be also adjusted by selecting how far the protrusions are extending away from the base of the applicator. In embodiments, air pressure may be used for extending spring-loaded protrusions from individual applicators. An inflatable outer bag may be used to uniformly press all applicators against the curved portions of the body with the same force.
