Simon BREITLER,Joerg LILL,Kurt PUENTENER,René TRUSSARDI
申请号：
US16690615
公开号：
US20200079807A1
申请日:
2019.11.21
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The invention comprises a process for the preparation of therapeutically valuable GalNAc cluster oligonucleotide conjugates. The process comprises the coupling of an alkali metal salt, earth alkali metal salt or a tetraalkylammonium salt of an oligonucleotide with a GalNAc cluster compound or with a salt thereof and a subsequent purification.
