The present invention relates to a humanized antibody that selectively binds to the 31.1 epitope on the A33 protein that is differentially expressed in cancers including lung cancer, ovarian cancer, pancreatic cancer, breast cancer, and colon cancer, and diagnostic uses thereof And therapeutic uses. [Selection] Figure 1A本発明は、肺癌、卵巣癌、膵臓癌、乳癌、及び結腸癌を含む癌に示差的に発現されているA33タンパク質上の31.1エピトープに選択的に結合するヒト化抗体、ならびにその診断用途及び治療用途に関する。【選択図】図1A