Process for the preparation of rapamycin derivatives

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专利权人:

Murat Acemoglu

发明人:

Murat Acemoglu,Sabine Pfeffer

申请号：

US12160110

公开号：

US08138344B2

申请日:

2007.01.22

申请国别(地区):

US

年份:

2012

代理人:

摘要：

Processes for the production of a 32-deoxorapamycin from a 32-iodo- or 32-hydroxyrapamycin, wherein the hydroxy group is substituted by the residue of an arylthionocarbonate or an arylthiocarbamate, in the presence of tris(trimethylsilyl)-silan and α,α′-azo-isobutyronitril in organic solvent and 32-deoxorapamycin in the form of a crystalline solvate.

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