Occlusive tissue dressings and methods including an elastomeric drape and a liquid component at least partially cross linked at least after one of drying and curing suitable for application at a dressing to skin interface in order to create a substantially air tight seal. The same or a different liquid component may be applied by a user at a tube to dressing interface in order to create a similar air tight seal around the tube if not occlusively sealed during its manufacture.
