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AGENT PORTEUR DE DISTRIBUTION D'ACIDE NUCLÉIQUE, KIT DE DISTRIBUTION D'ACIDE NUCLÉIQUE, ET PROCÉDÉ DE DISTRIBUTION D'ACIDE NUCLÉIQUE
专利权人:
Keio University
发明人:
申请号:
EP16807600.8
公开号:
EP3308789A1
申请日:
2016.06.10
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
The purpose of the present invention is to provide a nucleic acid delivery carrier, a nucleic acid delivery kit, and a nucleic acid delivery method which have an excellent effect of inhibiting cell death after nucleic acid delivery and have excellent efficiency of delivering nucleic acids into cells. This carrier for delivery of nucleic acids into cells comprises a liposome having a membrane fusion capability, wherein the liposome includes a cationic lipid as a membrane constituent, and the surface of the liposome is modified with a temperature-responsive polymer. This nucleic acid delivery carrier is optimally used to deliver nucleic acids into cervical cancer cells. This kit for delivering nucleic acids into cells includes the aforementioned delivery carrier. The nucleic acid delivery method for delivering nucleic acids into cells involves a step for contacting isolated cells with a complex of the aforementioned nucleic acid delivery carrier and nucleic acids, or, a step for dosing a non-human animal with a complex of the aforementioned nucleic acid delivery carrier and nucleic acids.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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