ALLEGRETTI, Marcello,BERTINI, Riccardo,BIZZARRI, Cinzia,CESTA, Maria Candida
申请号：
ES02777207
公开号：
ES2573531T3
申请日:
2002.09.25
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
Compounds of (R) -2-aryl-propionadim of formula (I): ** Formula ** wherein Ar is selected from: a) an Ara which is selected from the group consisting of 4-isobutylphenyl, 3-benzoyl-phenyl ； b) a phenyl group substituted in 3 by isopropyl, c) a 2- (phenylamino) -phenyl of formula (III c): ** Formula ** where substituents P1 and P2 indicate that the two phenyl groups each have independently, mono- or poly-substitutions with C1-C4 alkyl groups, C1-C3 alkoxy, chlorine, fluorine and / or trifluoromethyl, R is hydrogen； X is: - a linear C1-C6 alkylene, optionally substituted at C1 with a -CO2R4 wherein R4 is H； - a linear C1-C6 alkylene optionally substituted on C1 with a group -CONHR5 wherein R5 is OH； - (CH2) m-CO-NH- (CH2) n- where m and n are each independently an integer from 2 to 3； - - (CHR ') - CONH- (CH2) n where n is an integer from 2 to 3 and R' is a methyl, having absolute configuration R or S； - a phenyl or phenylmethylene group of the formula: ** Formula ** - or X, together with the N atom to which it is attached and the R1 group forms an azocycloaliphatic ring, the NR1R2R3 group represents a trimethylammonium, triethylammonium, N-cyclohexylmethyl group -N, N-dimethylammonium, N-cyclopentylamino- N, N-dimethylammonium, N-methyl-1-piperidinium, N-ethyl-1-piperidinium, N-methyl-4-morpholinium, N-methyl-4- thiomorpholinium, N-benzyl -N, N-dimethylammonium, N-allyl-1-piperidinium, 4-oxo-N-methyl-piperidinium, or X together with the N amino to which it is attached and with the group R1, forms a 5-6 heterocyclic ring nitrogen-containing members and the R2 and R3 substituents independently represent a methyl or cyclohexyl residue, Z- represents a pharmaceutically acceptable counterion of quaternary ammonium salts, or said compounds are (R) - {3- [2- (3) iodide -benzoylphenyl) -propionylamino] propyl} -N-isopropyl-N, N-dimethylammonium or iodide of (R) - {3- [2- (4-isobutylphenyl) -propionylamino] propyl} -N-ethyl-N, N-dimethylammonium.Compuestos de (R)-2-aril-propi
