EDWARDS, Hannah Joy,EVANS, David Michael,DAVIE, Rebecca Louise,ROOKER, David Philip,HEWISON, Steven John
申请号：
ES14753140
公开号：
ES2691084T3
申请日:
2014.08.14
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of formula (I), ** Formula ** wherein W is selected from CH and N； X is selected from CH, CH2-CH2, CH>； = CH, N and NH； Y is selected from CH2, CH, N, NH and O； in which the link between X and Y ("---") is saturated, unsaturated or aromatic； B is selected from i) a radical of formula II ** Formula ** and ii) a fused 6,5- or 6,6-heteroaromatic bicyclic ring, containing N and, optionally, one or two additional heteroatoms independently selected from N , O and S, which is optionally mono, di or trisubstituted with a substituent selected from alkyl, alkoxy, OH, halo, CN, COOR8, CONR8R9, CF3 and NR8R9； P is H and Q is -C (R20) (R21) NH2, or P is -C (R20) (R21) NH2 and Q is H； U and V are independently selected from C and N so that the aromatic ring containing U and V is phenyl, pyridine or pyridazine； R1 is absent when U is N； R2 is absent when V is N； or, when present, R1 and R2 are independently selected from H, alkyl, alkoxy, CN, halo and CF3； R3 is selected from H, alkyl, alkoxy, CN, halo and CF3； A is selected from phenyl substituted heteroaryl； and - (CH2) 0-3 phenyl optionally substituted with heteroaryl, - (CH2) 1-3-heteroaryl or - (CH2) 1-3-NR14R15； R8 and R9 are independently selected from H and alkyl； R20 and R21 are independently selected from H and alkyl, or they can together form a cycloalkyl ring or a cyclic ether； alkyl is a linear saturated hydrocarbon having up to 10 carbon atoms (C1-C10) or a branched saturated hydrocarbon of between 3 and 10 carbon atoms (C3-C10)； alkyl may be optionally substituted with 1 or 2 substituents independently selected from (C1-C6) alkoxy, OH, CN, CF3, COOR10, CONR10R11, fluoro and NR10R11； cycloalkyl is a monocyclic saturated hydrocarbon of between 3 and 7 carbon atoms； a cyclic ether is a monocyclic saturated hydrocarbon of between 4 and 7 carbon atoms, in which one of the ring carbons is replaced by an oxygen atom； alkoxy is a linear O-linked hydrocarbon of between 1 and 6 carbon atoms (C1-C6) or a branched
