CASWELL, JILL,JOHNSTON, JAMES,OLWILL, SHANE,BUICK, RICHARD,JAQUIN, THOMAS,DOHERTY, DECLAN,SCOTT, CHRISTOPHER
申请号：
NZ58847909
公开号：
NZ588479A
申请日:
2009.04.17
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Discloses a polyspecific antibody which binds Heparin-binding EGF-like growth factor (HBEGF) and amphiregulin (AREG) and inhibits the activity of both HBEGF and AREG. The polyspecific antibody has a VH domain with 3 CDRs from SEQ ID NO: 7 and a VL domain with 3 CDRs from SEQ ID NO: 8. Further disclosed is the use of the polyspecific antibody in the preparation of a medicament for treatment of a neoplastic disease or inflammatory associated disorder. The use of the antibody may be in combination with a selected chemotherapeutic agent or angiogenesis inhibitor. Further disclosed is a kit comprising (i) the polyspecific antibody and (ii) selected chemotherapeutic agent or angiogenesis inhibitor.
