The invention provides a process, especially for the efficient reuse of human bone material, the process comprising (i) screening a bone part, external from a body, on the suitability for reuse in a human body, (ii) optionally packaging the bone part,(iii) subjecting a bone part to a high pressure process, wherein the bone part enclosed by a package is subject to a pressure selected from the range of 450-800 Mpa for a period of time selected from the range of 1-60 minutes, (iv) optionally packaging the thus obtained high pressure process processed bone part, (v) transporting the packaged bone part to a processing stage, and (vi) removing the package and disintegrating at least part of the bone part into bone material.