Disclosed are the uses of compositions containing not less than 10% w/w ofOroxylin A, not less than 10% w/w ofBaicalein and not less than 2% w/w of Chrysin in inhibiting the activity andexpression of .beta. secretase. The invention also disclosesthe reduction of amyloid content in PS- 70 cells using the abovementionedcomposition. Further, the invention mentions the use of thecomposition for the therapeutic management of .beta. secretase mediateddisorders.